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Full-field Interferometric Imaging of Propagating Action Potentials

Penelitian - A promising non-invasive technique for measuring electrical activity in neurons and other cells works by observing how cells deform in response to changes in their electric potential. Existing methods for analyzing cells’ electrical activity are invasive and may affect natural cell behavior.

Now, Tong Ling and co-workers from Daniel Palanker’s lab at Stanford University in the US demonstrated a method that monitors changes in cell shapes during electrical spikes – or ‘action potentials’ - using quantitative phase microscopy.

Penelitian Full-field Interferometric Imaging of Propagating Action Potentials

Action potential occurs when the negatively-charged cell interior depolarizes due to a stimulus, triggering a rapid voltage change across the cell membrane. Ling’s team demonstrated that cells deform in response to these relatively large (0.1 V) voltage shifts, revealing exactly when action potentials occur. Their technique may facilitate non-invasive analysis of neuronal networks and other cellular activities.



Journal : Tong Ling et al. Full-field interferometric imaging of propagating action potentials, Light: Science & Applications, 12 December 2018, DOI:10.1038/s41377-018-0107-9

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