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Segmental Additive Tissue Engineering (SATE) new way of repairing bone

Penelitian - The New York Stem Cell Foundation (NYSCF) Research Institute developed a bone engineering technique called Segmental Additive Tissue Engineering (SATE). The technique allows researchers to combine bone segments engineered from stem cells to create a personalized large-scale graft and improve care for bone patients through regenerative medicine.

More than one million people per year suffer from bone fractures and as age gets weaker which causes later complications. Traumatic injuries from car accidents, domestic violence, and genetic malformations such as osteogenesis imperfecta cause very large and rapidly increasing loads.

Penelitian Segmental Additive Tissue Engineering (SATE) new way of repairing bone

"We hope SATE will improve the lives of millions of people suffering from bone injuries by trauma, cancer, osteoporosis, osteonecrosis, and other conditions. Our goal is to help these patients return to normal life and harness the power of regenerative medicine," NYSCF CEO Susan Solomon .

Bone defects are currently treated with a synthetic substitute or bone graft, but this method often triggers immune rejection, not forming the connective tissue or blood vessels needed for the functional bone. The bone graft produced from the patient's stem cells overcomes these limitations, but it is difficult to make the biotecher in proper size and shape.

"We make smaller individual bone parts and then combine them to create a graft that overcomes the current limitations in bone size and shape that can be planted in the laboratory" says NYSCF researcher Martina Sladkova.

The research team engineered the graft associated with a defect in the femur of a rabbit that affects about 30% of the total bone volume. Femur imaging gives a value of the size and shape of the defects to produce a graft model. They then partition the model into smaller segments and create a customized scaffold for each.

The team then placed this scaffold which was fitted with mesodermal progenitor cells derived from human-induced human stem cells into bioreactors specially designed to accommodate bone grubs of various sizes. Bioreactors ensure the development of tissue uniform throughout the graft.



The cells are integrated and grown in scaffolds where the bone graft segments are then combined into a mechanically stable graft using biocompatible bone adhesives or other orthopedic devices. SATE standardized, versatile, and easy to implement that allows for artificial bone grafts to be faster.

Journal : Martina Sladkova et al. Segmental Additive Tissue Engineering, Scientific Reportsvolume, 18 July 2018, DOI:10.1038/s41598-018-29270-4

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