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Wireless activates Kryptopterus bicirrhis protein for magnetic field

Scientists use magnetic wireless electromagnetic fields (EMF) to generate response from the contralateral forelimb Kryptopterus bicirrhis (glass catfish) in vivo. A team at F.M. The Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute, Baltimore, reports the development of new technologies for non-invasive cell function modulation.

K. bicirrhis is known to respond to electromagnetic fields, but Vijai Krishnan and colleagues test avoidance behavior in response to static and alternating static-field stimulation. The team used cloning expressions that identified electromagnetic perceptive gene (EPG) that encoded proteins that responded to EMF.

Penelitian Wireless activates Kryptopterus bicirrhis protein for magnetic field

The EPG gene has been cloned and expressed in mammalian cells, neuronal cultures and rat brains where immunohistochemistry shows EPG expression confined to mammalian cell membranes. Calcium imaging in mammalian cells and culture neurons expressing EPG suggests long-distance activation by EMF significantly increases intracellular calcium concentrations that indicate cellular stimulation.

"We report on the development of a new technology for remote, non-invasive modulation of cell function," said Krishnan et al.



The majority of the technologies available to manipulate cellular function and spatiotemporal-specific require the use of optics, drugs, radio wave heating or ultrasound. The identification of a remote-activated protein by non-invasive EMF is an unmet need that can complement the development of technologies dedicated to external control of in vivo cellular activity.

Journal : Vijai Krishnan et al. Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields, Scientific Reports, 08 June 2018, DOI:10.1038/s41598-018-27087-9

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