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Scientists report diversity of the Pandoravirus family

Penelitian ~ Scientists show most gene specific strains of giant pandoraviruses have no homologous and show statistical features that are comparable to intergenic regions. The research team at Aix-Marseille University reported the creation of de novo genes can contribute to the evolution of the Pandoraviridae genome.

Pandoraviruses have a 2.5 Mb genome size packaged in forms and bacteria-like dimensions found to infect Acanthamoeba remains the most complex virus since its discovery in 2013. Unique characteristics show different members of the giant virus that infects Acanthamoeba.

Penelitian Scientists report diversity of the Pandoravirus family

Matthieu Legendre from Aix Marseille Univ and colleagues isolated three new strains from different locations and environments to perform the first comparative genomic analysis of the Pandoraviridae family spread across the world. The genome is built by combining transcriptomic, proteomic, and bioinformatic analyzes to reveal many non-coding transcripts.

The scientists describe three new members of Pandoravirus quercus isolated from the ground in Marseille, Pandoravirus neocaledonia isolated from mangrove brackish water near the Noumea airport in New Caledonia, and Pandoravirus macleodensis isolated from a freshwater pool near Melbourne in Australia or 700 meters from the discovery site of Pandoravirus dulcis.

Light and electron microscopes make it possible to follow the viral replication cycle in Acanthamoeba castellanii where the five available pandoravirus strains in the laboratory and the Pandoravirus inopinatum genome provide comparative data to build an emerging global picture of families and improve the genome annotation of each individual strain.

The Pandoraviridae family is very diverse in terms of gene content. Much of the genome code for proteins without homologous in other cells or viruses raises the question of evolutionary origin. The purified virus is made up of over 200 different proteins and about half of them are shared by all strains. These large core proteins are consistent with very similar initial infection stages shown by different isolates.

Journal : Matthieu Legendre et al. Diversity and evolution of the emerging Pandoraviridae family, Nature Communications, 11 June 2018, DOI:10.1038/s41467-018-04698-4



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