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Four cups of coffee protect the heart and prolong life

Penelitian - Caffeine increases the movement of protein regulation to mitochondria, improves function and protects cardiovascular cells from damage. Scientists report findings to PLOS Biology about the benefits of other pleasures of delicious beverages that consume four cups of coffee may be physiologically relevant for protection-protective effects.

Caffeine consumption has been associated with a lower risk for type II diabetes, heart disease, and stroke, but the mechanisms underlying this protective effect are unclear. Previous scientists have also shown that the concentration of four caffeine cups increases the functional capacity of endothelial cells and involves mitochondria.

Penelitian Four cups of coffee protect the heart and prolong life

A new report by Judith Haendeler of HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine in Duesseldorf and colleagues showed p27 protein present in mitochondria in the major cell type of the heart. Mitochondria p27 promotes the migration of endothelial cells, protects the heart muscle cells from cell death and triggers the conversion of fibroblasts into contractile fiber cells.

"We are demonstrating caffeine actions that promote cardiovascular protection and repair through p27 mitochondrial action.It should be a better strategy to protect the heart muscle from damage. Coffee is good as an additional food in the elderly population," Haendeler said.

Caffeine induces the movement of p27 into the mitochondria, initiating a series of beneficial events and having a significant effect on the concentration reached by drinking four cups of coffee. Caffeine has been shown to be a protective against heart damage in pre-diabetic rats, obesity, and in older mice.

"Improving mitochondria p27 can serve as a potential therapeutic strategy not only in cardiovascular disease but also in improving healthspan," says Haendeler.

Journal : Niloofar Ale-Agha et al. CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine, PLOS Biology, June 21, 2018, DOI:10.1371/journal.pbio.2004408



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